Words In Context

Context Matters.

Human Stress: Eustress and Distress

“The body itself cannot physically discern between distress or eustress.”

There are stresses and there are stresses.   Your boss yelling at you causes mental distress.  Playing chess is mental eustress.   Getting a high voltage electric shock is distress for your body and your nervous system.   Getting the same nervous system synapses firing by practicing kung-fu is a form of eustress.  Then we get into all kinds of other issues.    I am fasting right now - seems stressful when your hunger is peaking but its actually a rest day for your digestive system.

Chemically speaking when we speak of stress - one refers to the Adrenocorticotropic hormone and the “Pituitary-Adrenanal System.”   

However, I view eustress of ALL kinds as being incredibly beneficial to the over all well being of humans.    Take any human system - immune, digestive, nervous, reproductive - you name it and it benefits from eustress.   The body has incredibly fine tuned mechanisms for healing and protecting each system.   The only time you actually get sick is when these mechanisms are for whatever reason not responding with vigor.  And that’s where stress come in.   Homeopaths have known this for a very long time:   

It is in the shadow of the visible suffering that the hidden treasure of healing can be revealed. 

Subdivision of the stress concept has become necessary as more recent work has led to such notions as “eustress,” “distress,” “systemic stress” and “local stress.” Confusion between stress as both an agent and a result can be avoided only by the distinction between “stress” and “stressor.” It is explained that the stress syndrome is — by definition — nonspecific in its causation. However, depending upon conditioning factors, which can selectively influence the reactivity of certain organs, the same stressor can elicit different manifestations in different individuals.   —Dr. Hans Selye M.D., Ph.D., D.Sc.

Lifespan - theory of mitohormesis

mitohormesis

According to theories of mitohormesis (i.e., mitochondrial hormesis), hormesis may also be induced by endogenously produced, potentially toxic agents. ((Note the similarities to the immune system’s reaction to opioids and/or pathogens)).    For example,mitochondria consume oxygen which generates free radicals (reactive oxygen species) as an inevitable by-product. It was previously proposed on a hypothetical basis that such free radicals may induce an endogenous response cumulating in increased defense capacity against exogenous radicals (and possibly other toxic compounds). Recent experimental evidence from Michael Ristow’s laboratory strongly suggests that this is indeed the case, and that such induction of endogenous free radical production extends life span of a model organism. Most importantly, this induction of life span is prevented by antioxidants, providing direct evidence that toxic radicals may mitohormetically exert life extending and health promoting effects.

Since mitochondrial activity was found to be increased in the before-mentioned studies, this effect cannot be explained by an excess of free radicals that might mark mitochondria for destruction by lysosomes, and that the free radicals act as a signal within the cell indicating which mitochondria are ready for destruction, according to Nick Lane.

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My personal opinion is that one possibility is that as you age your ability to produce antioxidants reduces.   In this event an occasional antioxidant supplement is probably not a bad idea.   However, taking them regularly creates a dependency on this supplement and will further reduce the body’s own natural anti-oxidant production.   It would then be better to create oxidation stress in your body via exercise which will in turn stimulate anti-oxidant production - not to mention endorphin production (remember the immune systems response to endorphin opioids).     

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http://en.wikipedia.org/wiki/Mitohormesis#Mitohormesis

Human Immunity

Ok so my first post on tumblr.   Gonna have to be a quick one.   So Immunity in humans.   Two types.   Innate and Adaptive.    Non-stop war inside and outside your body.   Mind-boggling defenses - watch for TLRs (Super Scouts).   Cross Kingdom.  13 TLRs.   TLR activation is the start of your innate immune system defense.  

Primer:   

http://www.youtube.com/watch?v=9zV7XeN0yes&feature=relmfu

http://www.youtube.com/watch?v=JKG8MQdHnh0

Funny and Brilliant:

http://www.youtube.com/watch?v=iVMIZy-Y3f8

TLR activation, over stimulation and eventual cry wolf syndrome could be a reason why opioids lose potency over time.   Interesting speculation is that you feel pleasure (anti-pain) upon TLR4 activation (Opioids as agonist).   Opioid abusers are known to have weak immunity.

Will post more later on adaptive immune system defenses.   

Nobel Prize in Medicine 2011:  http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/press.html

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